USC vs Oregon Football Odds - SportsBetting3.com

The Trojans will play the Ducks on Saturday, November 22nd, 2025. The matchup takes place at Autzen Stadium. Watch this exciting Week 13 matchup at 3:30 pm EST. Check local listings for coverage on CBS.

Learn more about College Football betting with our handy tutorial and guide. We explain spread, total and money line bets.

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Matchup Stats
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Key Matchup Stats

We're now in the home stretch of the 2025 college football season, with USC and Oregon meeting at Autzen Stadium for a key late-season matchup on Saturday, November 22nd, 2025. The playoffs are fast approaching, along with the annual Bowl games that kick off in December. Here's an overview of some important 2025 performance data for each team.

SportsBetting3.com Power Rankings - As we wrap up the 2025 regular season, USC has notched a 97.00 Big Ten Conference conference power ranking. On the other side of the gridiron, Oregon has a 98.00 Big Ten Conference power ranking.
Away USC - Looking at Week 13, USC heads into this matchup with a 2-2 record as an away team. This ranks them 3rd in the Big Ten Conference for away team wins in 2025. Remember that a team's overall record and schedule strength will affect whether or not they make a December bowl game or qualify for the playoffs.
Home Oregon - Meanwhile, Oregon has a 5-1 record as a home team for 2025. They currently rank 3rd in the Big Ten Conference for home team wins. Let's see if they can add another win to their record when they battle USC on Saturday, November 22nd, 2025.
Points Scored - Now late in the 2025 season, USC ranks 3rd (382) in the Big Ten Conference, with Oregon currently ranking 2nd (390) for points scored in the Big Ten Conference.
Points Against - USC currently stands 9th (217) in the Big Ten Conference for points scored by opponents in the 2025 college football season. Their opponent, Oregon, ranks 16th (137) in the Big Ten Conference for points against them as the 2025 college football season comes to a close.
Team Records - As we head into Week 13, USC has a 8-2 overall record for the 2025 regular season, with Oregon possessing a 9-1 standing for the 2025 college football season.

Paddy O'Parlay

The "Sports Network" talking heads have nothing on my Irish arse!

Get ready for a wild showdown between USC and Oregon this Saturday!

Autzen Stadium will be rocking as these two powerhouse teams clash in Week 13.

USC is ranked 97.00 and Oregon is ranked 98.00 in the Power Rankings.

USC has an 8-2 record while Oregon boasts a 9-1 standing.

We recommend BetRivers or BetMGM for a bet on this game. Review this game's prop bets and compare the best point spread, total, and moneylines from our partner sportsbooks below.

Best Trojans at Ducks Odds

**Best Point Spread Betting Odds**
Underdog USC	Favorite Oregon
+10.5 -115 BetMGM Bet	-10.5 -105 BetMGM Bet

Oregon has a -10.5 -105 point spread at BetMGM OH. They are the point spread favorite in this matchup. USC has a +10.5 -115 point spread at BetMGM OH. USC is the point spread underdog. Review how to bet on a point spread with our text and video tutorials.

**Best Total Betting Odds**
Over	Under
59.5 o -105 BetMGM Bet	59.5 u -115 BetMGM Bet

BetMGM has the best over line of 59.5 points. Risk $105 to win $100. BetMGM has the best under line of 59.5 points. Risk $115 to win $100. Our tutorial explains more about total bets.

**Best Moneyline Betting Odds**
Underdog USC	Favorite Oregon
+310 BetMGM Bet	-400 BetMGM Bet

Oregon is the -400 moneyline favorite. Risk $400 to win $100 on Oregon at BetMGM. USC is the +310 underdog at BetMGM. Risk $100 to win $310 on USC. Learn more about how to bet on money lines.

Matchup Odds FAQs

What is the point spread for the USC vs Oregon College Football game on Saturday, November 22nd, 2025?

Oregon is a -10.5 -105 point spread favorite at BetMGM, while USC is a +10.5 -115 point spread underdog at BetMGM.

What is the over-under total line for the USC vs Oregon College Football game on Saturday, November 22nd, 2025?

The best over line is 59.5 -105 points at BetMGM, which means you risk $105 to win $100 betting the over. The best under line is 59.5 -115 points at BetMGM, and that means you risk $115 to win $100 betting the under.

What is the moneyline for the USC vs Oregon College Football game on Saturday, November 22nd, 2025?

Oregon is a -400 moneyline favorite at BetMGM and USC is a +310 moneyline underdog at BetMGM.

College Football Odds Example

College Football Odds and Outcomes Explained
Game	BetMGM Bet
USC Oregon 11/22/25 3:30pm EST	+10.5 -115 -10.5 -105

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Underdog USC - USC bettors risk $100 to win $86.96 at -115 odds.

A +10.5 USC underdog bet wins if they lose by 10 or fewer, tie, or win outright. Your bet loses if they lose by 11 or more.

Favorite Oregon - Oregon bettors risk $100 to win $95.24 at -105 odds.

A -10.5 Oregon favorite bet wins if they win by 11 or more. Your bet loses if they win by 10 or fewer, tie, or lose outright.

USC at Oregon Prop Bets

Important Note: Some states expressly forbid individual college athlete prop bets. The following wagers may not be available depending on your particular state laws.

College Football Prop Bets
+ Displays more odds
	BetMGM Bet
USC Oregon No Touchdown To Score 1st Touchdown 11/22/25 3:30pm EST	+160 -235 +10000 Bet
USC Oregon Game to Overtime 11/22/25 3:30pm EST	Yes +1250 No -10000 Bet
USC Oregon Both Teams Score 10+ 11/22/25 3:30pm EST	Yes -2000 No +825 Bet
USC Oregon Both Teams Score 20+ 11/22/25 3:30pm EST	Yes -200 No +155 Bet
	BetMGM
USC Oregon Both Teams Score 30+ 11/22/25 3:30pm EST	Yes +300 No -425 Bet

Recent Meetings Since 2021

Recent Meetings Since 2021
Week	Game	Result	Margin
2025 Week 13	USC vs Oregon Saturday, November 22nd, 2025	ORE 42, USC 27 Autzen Stadium	Oregon by 15
2023 Week 11	USC vs Oregon Saturday, November 11th, 2023	ORE 36, USC 27 Autzen Stadium	Oregon by 9

Team Standings

2025-2026 College Football Regular Season Standings - USC, Oregon
Team	Conf	Conf%	W	L	PF	PA	Home	Away	Strk
#5 Oregon	8-1	0.889	11	1	458	178	6-1	5-0	W6
#16 USC	7-2	0.778	9	3	438	269	7-0	2-3	W1

USC & Oregon Futures Odds

Latest NCAA Championship odds, if available, for each team. Review odds for other teams and learn the best College Football bets.

USC Championship Odds

No NCAA College Football Championship TM USC YR: futures available

Oregon Championship Odds

2025-26 Oregon NCAA College Football Championship Odds
Team
OH,US ncaafb Evnum: 1 Odds Pending

USC & Oregon Team Pages

Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

Team Schedules & Results

2025-26 USC Games & Results
Week	Matchup	Date & Result
Week 1	Missouri State vs USC	USC 73, MOST 13 Saturday, August 30th, 2025
Week 2	Georgia Southern vs USC	USC 59, GASO 20 Saturday, September 6th, 2025
Week 3	USC vs Purdue	USC 33, PUR 17 Saturday, September 13th, 2025
Week 4	Michigan State vs USC	USC 45, MSU 31 Saturday, September 20th, 2025
Week 5	USC vs Illinois	ILL 34, USC 32 Saturday, September 27th, 2025
Week 7	Michigan vs USC	USC 31, MICH 13 Saturday, October 11th, 2025
Week 8	USC vs Notre Dame	ND 34, USC 24 Saturday, October 18th, 2025
Week 10	USC vs Nebraska	USC 21, NEB 17 Saturday, November 1st, 2025
Week 11	Northwestern vs USC	USC 38, NU 17 Friday, November 7th, 2025
Week 12	Iowa vs USC	USC 26, IOWA 21 Saturday, November 15th, 2025
Week 13	USC vs Oregon	ORE 42, USC 27 Saturday, November 22nd, 2025
Week 14	UCLA vs USC	USC 29, UCLA 10 Saturday, November 29th, 2025
Bowls	USC vs TCU Valero Alamo Bowl	Tuesday, December 30th, 2025 9:00 pm EST

2025-26 Oregon Games & Results
Week	Matchup	Date & Result
Week 1	Montana State vs Oregon	ORE 59, MTST 13 Saturday, August 30th, 2025
Week 2	Oklahoma State vs Oregon	ORE 69, OKST 3 Saturday, September 6th, 2025
Week 3	Oregon vs Northwestern	ORE 34, NU 14 Saturday, September 13th, 2025
Week 4	Oregon State vs Oregon	ORE 41, ORST 7 Saturday, September 20th, 2025
Week 5	Oregon vs Penn State	ORE 30, PSU 24 (2OT) Saturday, September 27th, 2025
Week 7	Indiana vs Oregon	IU 30, ORE 20 Saturday, October 11th, 2025
Week 8	Oregon vs Rutgers	ORE 56, RUTG 10 Saturday, October 18th, 2025
Week 9	Wisconsin vs Oregon	ORE 21, WIS 7 Saturday, October 25th, 2025
Week 11	Oregon vs Iowa	ORE 18, IOWA 16 Saturday, November 8th, 2025
Week 12	Minnesota vs Oregon	ORE 42, MINN 13 Friday, November 14th, 2025
Week 13	USC vs Oregon	ORE 42, USC 27 Saturday, November 22nd, 2025
Week 14	Oregon vs Washington	ORE 26, WASH 14 Saturday, November 29th, 2025
CFP	James Madison vs Oregon CFP First Round Game	Saturday, December 20th, 2025 7:30 pm EST

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the USC vs Oregon College Football Game

Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Saturday, November 22nd, 2025 at 3:30 pm EST, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
Tap to the sportsbook's College Football page, look for the USC vs Oregon Game.
Navigate to the sportsbook's College Football page. Next, look for live or upcoming matchups. Select the USC vs Oregon Game.
Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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